相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。The hypoxia signalling pathway in haematological malignancies
Marta Irigoyen et al.
ONCOTARGET (2017)
Effect of pantoprazole to enhance activity of docetaxel against human tumour xenografts by inhibiting autophagy
Q. Tan et al.
BRITISH JOURNAL OF CANCER (2015)
Mechanisms of Drug Resistance Related to the Microenvironment of Solid Tumors and Possible Strategies to Inhibit Them
Qian Tan et al.
CANCER JOURNAL (2015)
Phase I/II study of the hypoxia-activated prodrug PR104 in refractory/relapsed acute myeloid leukemia and acute lymphoblastic leukemia
Marina Konopleva et al.
HAEMATOLOGICA (2015)
Immunological mechanisms of the antitumor effects of supplemental oxygenation
Stephen M. Hatfield et al.
SCIENCE TRANSLATIONAL MEDICINE (2015)
Hypoxia/HIF1′ induces lapatinib resistance in ERBB2-positive breast cancer cells via regulation of DUSP2
Sergey V. Karakashev et al.
ONCOTARGET (2015)
Phase I/II study of the hypoxia-activated prodrug PR104 in refractory/relapsed acute myeloid leukemia and acute lymphoblastic leukemia
Marina Konopleva et al.
HAEMATOLOGICA (2015)
The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence
Holly E. Barker et al.
NATURE REVIEWS CANCER (2015)
Immune modulation for cancer therapy
J. Naidoo et al.
BRITISH JOURNAL OF CANCER (2014)
Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma
Xiao-Hong Ma et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection
Stephen M. Hatfield et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2014)
Targeting Cancer-Derived Adenosine: New Therapeutic Approaches
Arabella Young et al.
CANCER DISCOVERY (2014)
Survivin family proteins as novel molecular determinants of doxorubicin resistance in organotypic human breast tumors
Alice Faversani et al.
BREAST CANCER RESEARCH (2014)
Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology
Gregg L. Semenza
Annual Review of Pathology-Mechanisms of Disease (2013)
Excessive MET signaling causes acquired resistance and addiction to MET inhibitors in the MKN45 gastric cancer cell line
Yohei Funakoshi et al.
INVESTIGATIONAL NEW DRUGS (2013)
Dual PI3K/mTOR inhibitor NVP-BEZ235 suppresses hypoxia-inducible factor (HIF)-1α expression by blocking protein translation and increases cell death under hypoxia
Jayashree Karar et al.
CANCER BIOLOGY & THERAPY (2012)
Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent
Natasha Sharma et al.
CANCER LETTERS (2012)
Light-Chain 3A Autophagic Activity and Prognostic Significance in Non-small Cell Lung Carcinomas
Georgia Karpathiou et al.
CHEST (2011)
HSP90 Inhibition Is Effective in Breast Cancer: A Phase II Trial of Tanespimycin (17-AAG) Plus Trastuzumab in Patients with HER2-Positive Metastatic Breast Cancer Progressing on Trastuzumab
Shanu Modi et al.
CLINICAL CANCER RESEARCH (2011)
The Role of Autophagy in Cancer: Therapeutic Implications
Zhineng J. Yang et al.
MOLECULAR CANCER THERAPEUTICS (2011)
Inhibition of autophagy by 3-MA potentiates cisplatin-induced apoptosis in esophageal squamous cell carcinoma cells
Donglei Liu et al.
MEDICAL ONCOLOGY (2011)
Beclin-1 and LC3A expression in cutaneous malignant melanomas: a biphasic survival pattern for beclin-1
Efthimios Sivridis et al.
MELANOMA RESEARCH (2011)
Omeprazole Inhibits Proliferation and Modulates Autophagy in Pancreatic Cancer Cells
Andrej Udelnow et al.
PLOS ONE (2011)
Autophagy is a therapeutic target in anticancer drug resistance
Suning Chen et al.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2010)
Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of the Combination of Sorafenib and Tanespimycin
Ulka N. Vaishampayan et al.
CLINICAL CANCER RESEARCH (2010)
Hypoxia-induced autophagy: cell death or cell survival?
Nathalie M. Mazure et al.
CURRENT OPINION IN CELL BIOLOGY (2010)
Progress in the unraveling of the endoplasmic reticulum stress/autophagy pathway and cancer: Implications for future therapeutic approaches
Stephen M. Schleicher et al.
DRUG RESISTANCE UPDATES (2010)
pH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity
Angelo De Milito et al.
INTERNATIONAL JOURNAL OF CANCER (2010)
Hypoxia Suppression of Bim and Bmf Blocks Anoikis and Luminal Clearing during Mammary Morphogenesis
Kelly A. Whelan et al.
MOLECULAR BIOLOGY OF THE CELL (2010)
Hypoxia-Inducible Factors and the Response to Hypoxic Stress
Amar J. Majmundar et al.
MOLECULAR CELL (2010)
Multiple receptor tyrosine kinases regulate HIF-1α and HIF-2α in normoxia and hypoxia in neuroblastoma: implications for antiangiogenic mechanisms of multikinase inhibitors
M. B. Nilsson et al.
ONCOGENE (2010)
HIF-1α-dependent autophagy protects HeLa cells from fenretinide (4-HPR)-induced apoptosis in hypoxia
Xiao-Wen Liu et al.
PHARMACOLOGICAL RESEARCH (2010)
Inhibition of Autophagy by 3-MA Enhances the Effect of 5-FU-Induced Apoptosis in Colon Cancer Cells
Jie Li et al.
ANNALS OF SURGICAL ONCOLOGY (2009)
Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells
Cristian Bellodi et al.
JOURNAL OF CLINICAL INVESTIGATION (2009)
Effect of hypoxia-inducible factor-1α on transcription of survivin in non-small cell lung cancer
Yu-Qing Chen et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2009)
Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains
Gregory Bellot et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated repression of hypoxia-inducible factor-1
Dong Hoon Shin et al.
BLOOD (2008)
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia
Huafeng Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
William G. Kaelin et al.
MOLECULAR CELL (2008)
Autophagy fights disease through cellular self-digestion
Noboru Mizushima et al.
NATURE (2008)
Hypoxia and cancer
M. Christiane Brahimi-Horn et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2007)
Drug resistance and the solid tumor microenvironment
Olivier Tredan et al.
JOURNAL OF THE NATIONAL CANCER INSTITUTE (2007)
Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer
Aleksandra Franovic et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Proton pump inhibitors induce apoptosis of human B-cell tumors through a caspase-independent mechanism involving reactive oxygen species
Angelo De Milito et al.
CANCER RESEARCH (2007)
A selective small molecule inhibitor of c-Met, PHA665752, inhibits tumorigenicity and angiogenesis in mouse lung cancer xenografts
Neelu Puri et al.
CANCER RESEARCH (2007)
Role of hypoxia inducible factor-1 alpha in modulation of apoptosis resistance
M. Kilic et al.
ONCOGENE (2007)
Bevacizumab: An angiogenesis inhibitor for the treatment of solid malignancies
Ted Shih et al.
CLINICAL THERAPEUTICS (2006)
Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy
James L. Tatum et al.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2006)
Role of hypoxia-inducible factor (HIF)-1α-versus HIF-2α in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-1, or loss of von Hippel-Lindau function:: Implications for targeting the HIF pathway
Veronica A. Carroll et al.
CANCER RESEARCH (2006)
Hypoxia regulates cross-talk between Syk and Lck leading to breast cancer progression and angiogenesis
G Chakraborty et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Reversing hypoxic cell chemoresistance in vitro using genetic and small molecule approaches targeting hypoxia inducible factor-1
LM Brown et al.
MOLECULAR PHARMACOLOGY (2006)
Small interfering RNA expression vector targeting hypoxia-inducible factor 1 alpha inhibits tumor growth in hepatobiliary and pancreatic cancers
T Mizuno et al.
CANCER GENE THERAPY (2006)
AMPK: A key sensor of fuel and energy status in skeletal muscle
DG Hardie et al.
PHYSIOLOGY (2006)
Autophagy and signaling: their role in cell survival and cell death
P Codogno et al.
CELL DEATH AND DIFFERENTIATION (2005)
Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity
DH Kong et al.
CANCER RESEARCH (2005)
Evaluating hypoxia-inducible factor-1α as a cancer therapeutic target via inducible RNA interference in vivo
LM Li et al.
CANCER RESEARCH (2005)
The role of p53 in hypoxia-induced apoptosis
EM Hammond et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Identification of novel small molecule inhibitors of hypoxia-inducible factor-1 that differentially block hypoxia-inducible factor-1 activity and hypoxia-inducible factor-1α induction in response to hypoxic stress and growth factors
NM Chau et al.
CANCER RESEARCH (2005)
Bevacizurnab in combination with fluorouracil and leucovorin: An active regimen for first-line metastatic colorectal cancer
HI Hurwitz et al.
JOURNAL OF CLINICAL ONCOLOGY (2005)
ERBB receptors and cancer: The complexity of targeted inhibitors
NE Hynes et al.
NATURE REVIEWS CANCER (2005)
Anoxia is necessary for tumor cell toxicity caused by a low-oxygen environment
I Papandreou et al.
CANCER RESEARCH (2005)
Hypoxia-mediated down-regulation of bid and bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance
JT Erler et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
trans-3,4,5′-trihydroxystibene inhibits hypoxia-inducible factor 1α and vascular endothelial growth factor expression in human ovarian cancer cells
ZX Cao et al.
CLINICAL CANCER RESEARCH (2004)
Selective induction of apoptosis with proton pump inhibitor in gastric cancer cells
M Yeo et al.
CLINICAL CANCER RESEARCH (2004)
Tumor microenvironmental physiology and its implications for radiation oncology
P Vaupel
SEMINARS IN RADIATION ONCOLOGY (2004)
Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway
AL Kung et al.
CANCER CELL (2004)
9-β-D-arabinofuranosyl-2-fluoroadenine inhibits expression of vascular endothelial growth factor through hypoxia-inducible factor-1 in human ovarian cancer cells
J Fang et al.
MOLECULAR PHARMACOLOGY (2004)
Role of hypoxia-inducible factor 1α in gastric cancer cell growth, angiogenesis, and vessel maturation
O Stoeltzing et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2004)
Loss of HIF-1α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis
N Tang et al.
CANCER CELL (2004)
Treatment with siRNA and antisense oligonucleotides targeted to Hif-1α induced apoptosis in human tongue squamous cell carcinomas
QZ Zhang et al.
INTERNATIONAL JOURNAL OF CANCER (2004)
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
S Pennacchietti et al.
CANCER CELL (2003)
The hypoxic tumour microenvironment and metastatic progression
P Subarsky et al.
CLINICAL & EXPERIMENTAL METASTASIS (2003)
Widespread, hypoxia-inducible expression of HIF-2α in distinct cell populations of different organs
MS Wiesener et al.
FASEB JOURNAL (2002)
IAP proteins: Blocking the road to death's door
GS Salvesen et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)
Gene promoter of apoptosis inhibitory protein IAP2: identification of enhancer elements and activation by severe hypoxia
Z Dong et al.
BIOCHEMICAL JOURNAL (2002)
Hypoxia links ATR and p53 through replication arrest
EM Hammond et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Dephosphorylated hypoxia-inducible factor 1α as a mediator of p53-dependent apoptosis during hypoxia
H Suzuki et al.
ONCOGENE (2001)
Up-regulation of apoptosis inhibitory protein IAP-2 by hypoxia - HIF-1-independent mechanisms
Z Dong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Increased cellular hypoxia and reduced proliferation of both normal and leukaemic cells during progression of acute myeloid leukaemia in rats
PO Jensen et al.
CELL PROLIFERATION (2000)
Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
RK Bruick
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore
C Vande Velde et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)