期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 18, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/ijms18112340
关键词
vitamin D; VDR; preterm birth; GDM; preeclampsia; fetal growth restriction
资金
- Medical Faculty of the Ludwig-Maximilians-Universitat Munchen (LMU Munich)
Vitamin D, besides its classical role in bone metabolism, plays a distinct role in multiple pathways of the feto-maternal unit. Calcitriol is the major active ligand of the nuclear vitamin D receptor (VDR). The vitamin D receptor (VDR) is expressed in different uteroplacental parts and exerts a variety of functions in physiologic pregnancy. It regulates decidualisation and implantation, influences hormone secretion and placental immune modulations. This review highlights the role of the vitamin D receptor in physiologic and disturbed pregnancy, as preeclampsia, fetal growth restriction, gestational diabetes and preterm birth. We discuss the existing literature regarding common VDR polymorphisms in these pregnancy disorders.
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