期刊
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
卷 40, 期 2, 页码 271-280出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ijmm.2017.3036
关键词
protein phosphorylation; kinase; phosphatase; phospho-signaling networks; cancer; drug target
Protein phosphorylation is an important cellular regulatory mechanism as many enzymes and receptors are activated/deactivated by phosphorylation and dephosphorylation events, by means of kinases and phosphatases. In particular, the protein kinases are responsible for cellular transduction signaling and their hyperactivity, malfunction or overexpression can be found in several diseases, mostly tumors. Therefore, it is evident that the use of kinase inhibitors can be valuable for the treatment of cancer. In this review, we discuss the mechanism of action of phosphorylation, with particular attention to the importance of phosphorylation under physiological and pathological conditions. We also discuss the possibility of using kinase inhibitors in the treatment of tumors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据