Association of spontaneous abortion andUreaplasma parvumdetected in placental tissue

Spontaneous abortion is considered a public health problem having several causes, including infections. Among the infectious agents, bacteria of the vaginal microbiota andUreaplasma parvumhave been associated with abortion, but their participation needs to be further elucidated. This study aims to evaluate the influence ofMollicuteson the development of spontaneous abortion. Women who underwent spontaneous abortion and those with normal birth (control) were studied. Samples of cervical mucus (CM) and placental tissue were collected to identifyMollicutesusing the quantitative polymerase chain reaction methodology. Eighty-nine women who had a miscarriage and 20 women with normal pregnancies were studied. The presence ofMollicutesin placental tissue increased the chance of developing miscarriage sevenfold. The prevalence ofU. parvumin women who experienced spontaneous abortion was 66.3% in placental tissue. A positive association was observed between the detection ofU. parvumin samples of placental tissue and abortion. There was a significant increase in microbial load in placental tissue forM. hominis, U. urealyticumandU. parvumcompared to the control group. Detection ofU. parvumin CM in pregnant women can ascend to the region of the placental tissue and trigger a spontaneous abortion.