期刊
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
卷 17, 期 10, 页码 1327-1332出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijms.45960
关键词
Osteoblastic; Infection; Staphylococcus Aureus; Antimicrobial Peptides
资金
- National Natural Science Foundation of China [31970090, 81172183, 31470932]
Bone infection is difficult to cure, and relapse frequently occurs, which is a major treatment problem. One of the main reasons for the refractory and recurrent nature of bone infection is that bacteria, such as Staphylococcus aureus (S. aureus), can be internalized into osteoblasts after infecting bone tissue, thereby avoiding attack by the immune system and antibiotics. Understanding how bacteria (such as S. aureus) are internalized into osteoblasts is key to effective treatment. S. aureus is the most common pathogenic bacterium that causes bone infection. This paper reviews the literature, analyzes the specific process of osteoblastic S. aureus infection, and summarizes specific treatment strategies to improve bone infection treatment.
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