Syntheses of α-CF3-α-quaternary ketonesvia p-quinone methides and their derivatization to compounds with successively congested stereogenic centers

New and successful results for the construction of new and structurally interesting compounds are reportedviaN-heterocyclic carbene (NHC)-catalyzed 1,6-conjugate additions of a variety of aldehydes to delta-CF3-delta-substitutedp-quinone methides generatedin situ, and the products are used for the 1,2-addition reactions of appropriate metal nucleophiles, enabling us to furnish highly diastereoselective products with a unique successive quaternary carbon-tertiary alcohol framework (up to dr = >99 : 1).