期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 34, 期 -, 页码 37-45出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2015.01.008
关键词
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资金
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/D007585/1, BB/G006865/1, BB/H013849/1]
- State Key Laboratory of Cognitive Neuroscience and Learning
- Jane and Aatos Erkko Foundation Fellowship
- Leverhulme Trust [RPG-2012-567]
- BBSRC [BB/J009253/1, BB/G006865/1, BB/H013849/1, BB/M007006/1, BB/M009564/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/D007585/1, BB/G006865/1, BB/J009253/1, BB/M007006/1, BB/M009564/1, BB/H013849/1] Funding Source: researchfish
Phototransduction in Drosophila's microvillar photoreceptors is mediated by phospholipase C (PLC) resulting in activation of two distinct Ca2+-permeable channels, TRP and TRPL. Here we review recent evidence on the unresolved mechanism of their activation, including the hypothesis that the channels are mechanically activated by physical effects of PIP2 depletion on the membrane, in combination with protons released by PLC. We also review molecularly explicit models indicating how Ca2+-dependent positive and negative feedback along with the ultracompartmentalization provided by the microvillar design can account for the ability of fly photoreceptors to respond to single photons 10-100x more rapidly than vertebrate rods, yet still signal under full sunlight.
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