期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 31, 期 -, 页码 26-32出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2014.07.020
关键词
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资金
- Hungarian Scientific Research Fund [OTKA K83251, NNF 85659]
- European Research Council [ERC-2011-ADG-294313]
- European Research Council (SERRACO)
- EU FP [604102]
Sharp-wave-ripple complexes (SWRs) and interictal-spikes are physiological and pathological forms of irregularly occurring transient high activity events in the hippocampal EEG. They share similar features and carry high-frequency oscillations with different spectral features. Recent results reveal similarities and differences in the generation of the two types of transients, and argue that parvalbumin containing basket cells (PVBCs) are crucial in synchronizing neuronal activity in both cases. SWRs are generated in the reciprocally connected network of inhibitory PVBCs, while in the pathological case, synchronous failure of perisomatic inhibition triggers massive pyramidal cell burst firing. While physiological ripple oscillation is primarily the result of phasic perisomatic inhibitory currents, pathological high-frequency ripples are population spikes of partially synchronous, massively bursting, uninhibited pyramidal cells.
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