期刊
INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS
卷 19, 期 7, 页码 619-628出版社
BEGELL HOUSE INC
DOI: 10.1615/IntJMedMushrooms.2017021241
关键词
antimelanomic effect; endopolysaccharides; immunostimulation; laccase; low-molecular weight compounds; medicinal mushrooms; white rot fungi
Three bioactive fractions isolated from Cerrena unicolor cultures-crude endopolysaccharide (c-EPS), laccase, and a subfraction of low-molecular weight secondary metabolites-were used to determine potential cytotoxic effects on the mouse melanoma B16-F10 cell line (American Type Culture Collection CRL-6475). The results obtained prove that all examined fractions exhibited activity against the investigated tumor cells. In addition, an evident immunomodulatory effect of the c-EPS fraction was observed. Our results show that the levels of 2 cytokines (tumor necrosis factor-alpha and chemokine ligand 2) in mouse inner medullary collecting duct mIMCD-3 cells (American Type Culture Collection CRL-2123) stimulated by c-EPS were significantly higher. A lipopolysaccharide model was used at the same concentration (10 mu g/mL) as a positive control.
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