4.4 Article

Differentiation of Staphylococcus argenteus (formerly: Staphylococcus aureus clonal complex 75) by mass spectrometry from S. aureus using the first strain isolated from a wild African great ape

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出版社

ELSEVIER GMBH
DOI: 10.1016/j.ijmm.2016.11.003

关键词

Staphylococcus argenteus; Staphylococcus aureus; Staphylococcus schweitzeri; Gorilla gorilla ssp gorilla; MALDI-TOF MS; Virulence determinants

资金

  1. Deutsches Zentrum fur Infektionsforschung (DZIF) [TTU 08.902]
  2. Fundacao para a Ciencia e a Tecnologia (FCT) [SFRH/BD/66166/2009]
  3. BONFOR funds of the Medical Faculty of the University of Bonn
  4. funds of the Centre International de Recherches Medicales de Franceville (CIRMF)
  5. Institut de Recherche pour le Developpement (IRD)
  6. Fundação para a Ciência e a Tecnologia [SFRH/BD/66166/2009] Funding Source: FCT

向作者/读者索取更多资源

The species Staphylococcus argenteus was separated recently from Staphylococcus aureus (Tong S.Y., F. Schaumburg, M.J. Ellington, J. Corander, B. Pichon, F. Leendertz, S.D. Bentley, J. Parkhill, D.C. Holt, G. Peters, and P.M. Giffard, 2015). The objective of this work was to characterise the genome of a non-human S. argenteus strain, which had been isolated from the faeces of a wild-living western lowland gorilla in Gabon, and analyse the spectrum of this species in matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). The full genome sequence revealed a scarcity of virulence genes and absence of resistance genes, indicating a decreased virulence potential compared to S. aureus and the human methicillin-resistant S. argenteus isolate MSHR1132(T). Spectra obtained by MALDI-TOF MS and the analysis of available sequences in the genome databases identified several MALDI-TOF MS signals that clearly differentiate S. argenteus, the closely related Staphylococcus schweitzeri and S. aureus. In conclusion, in the absence of biochemical tests that identify the three species, mass spectrometry should be employed as method of choice. (C) 2016 Elsevier GmbH. All rights reserved.

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