期刊
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
卷 105, 期 -, 页码 1-10出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ijmedinf.2017.05.016
关键词
Image analysis; Pattern recognition; Melanoma diagnosis; Skin lesions; Plain-photography images
Objective: The aim of this study was to propose features that evaluate pictorial differences between melanocytic nevus (mole) and melanoma lesions by computer-based analysis of plain photography images and to design a cross-platform, tunable, decision support system to discriminate with high accuracy moles from melanomas in different publicly available image databases. Material and methods: Digital plain photography images of verified mole and melanoma lesions were down-loaded from (i) Edinburgh University Hospital, UK, (Dermofit, 330 moles/70 melanomas, under signed agreement), from 5 different centers (Multicenter, 63 moles/25 melanomas, publicly available), and from the Groningen University, Netherlands (Groningen, 100 moles/70 melanomas, publicly available). Images were processed for outlining the lesion-border and isolating the lesion from the surrounding background. Fourteen features were generated from each lesion evaluating texture (4), structure (5), shape (4) and color (1). Features were subjected to statistical analysis for determining differences in pictorial properties between moles and melanomas. The Probabilistic Neural Network (PNN) classifier, the exhaustive search features selection, the leave-one-out (LOO), and the external cross-validation (ECV) methods were used to design the PR-system for discriminating between moles and melanomas. Results: Statistical analysis revealed that melanomas as compared to moles were of lower intensity, of less homogenous surface, had more dark pixels with intensities spanning larger spectra of gray-values, contained more objects of different sizes and gray-levels, had more asymmetrical shapes and irregular outlines, had abrupt intensity transitions from lesion to background tissue, and had more distinct colors. The PR-system designed by the Dermofit images scored on the Dermofit images, using the ECV, 94.1%, 82.9%, 96.5% for overall accuracy, sensitivity, specificity, on the Multicenter Images 92.0%, 88%, 93.7% and on the Groningen Images 76.2%, 73.9%, 77.8% respectively. Conclusion: The PR-system as designed by the Dermofit image database could be fine-tuned to classify with good accuracy plain photography moles/melanomas images of other databases employing different image capturing equipment and protocols.
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