期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 30, 期 -, 页码 59-65出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2014.08.008
关键词
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资金
- Simons Initiative on Autism
- Simons Initiative on Autism and the Brain at MIT
- NIH/NICHD [R37 HD028341]
- Defense Advanced Research Projects Agency
- U.S. Army Research Office [W911NF-10-1-0059]
- EMBO Long-term Fellowship
- NIH/NIMH [R01 MH081201]
- Simons Foundation Autism Research Initiative
Increasing evidence implicates abnormalities in corticostriatal circuits in the pathophysiology of obsessive compulsive disorder (DOD) and OC-spectrum disorders. Parallels between the emergence of repetitive, compulsive behaviors and the acquisition of automated behaviors suggest that the expression of compulsions could in part involve loss of control of such habitual behaviors. The view that striatal circuit dysfunction is involved in OC-spectrum disorders is strengthened by imaging and other evidence in humans, by discovery of genes related to OCD syndromes, and by functional studies in animal models of these disorders. We highlight this growing concordance of work in genetics and neurobiology suggesting that frontostriatal circuits, and their links with basal ganglia, thalamus and brainstem, are promising candidates for therapeutic intervention in DOD.
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