期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 8, 期 26, 页码 5722-5728出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0tb00149j
关键词
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资金
- National Key Research and Development Program of China [2017YFA0104604]
- National Natural Science Foundation of China [31871407, 31741083, 31870831]
- Natural Science Foundation of Shandong Province [ZR2018MB042]
A new mitochondria-targeted fluorescent probe RBC, constructed using a coumarin moiety which was selected as the donor and a benzothiazole derivative as the acceptor, for SO(2)derivatives (HSO3-/SO32-) was presented. The probe designed on a new FRET platform showed high selectivity and a low detection limit. Importantly, the probe could respond to HSO3-/SO(3)(2-)within 35 s. Furthermore, the probe could target mitochondria and was successfully used for fluorescence imaging of endogenous bisulfite in HepG2 with low cytotoxicity, which significantly assisted in cancer diagnosis.
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