期刊
JOURNAL OF MATERIALS CHEMISTRY B
卷 8, 期 26, 页码 5694-5706出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0tb01002b
关键词
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资金
- National Natural Science Foundation of China [51973058, 31870963, 31760265]
- Key Research and Development Program of Jiangxi Province [20192ACB80008]
Mimicking the morphological structure of native blood vessels is critical for the development of vascular grafts. Herein, small-diameter composite vascular grafts that integrate the nanofibrous bacterial cellulose (BC) and submicrofibrous cellulose acetate (CA) were fabricatedviaa combined electrospinning and step-by-stepin situbiosynthesis. Scanning electron microscopy (SEM) observation shows the nano/submicro-fibrous morphology and well-interconnected porous structure of the BC/CA grafts. It is found that the BC/CA graft with a suitable BC content demonstrates lower potential of thrombus formation and enhanced endothelialization as compared to the BC and CA counterparts. Western blotting and RT-qPCR results suggest that the BC/CA-2 graft promotes endothelialization by improving expressions of genes vWF-1 and CD31 and protein CD31. Thein vivotests demonstrate much lower inflammatory response to the BC/CA graft. These results suggest that the BC/CA graft shows a great potential as an artificial graft for rapid formation of an endothelial cell monolayer.
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