期刊
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
卷 54, 期 -, 页码 77-84出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijid.2016.11.415
关键词
Plasmid-mediated colistin; Colistin resistance; Multi-drug resistant bacteria
资金
- Global Antibiotic Resistance Partnership - Bill&Melinda Gates Foundation
Objective: The widespread use of antibiotics in humans and animals has contributed to growing rates of antibiotic resistance. Previously treatable bacterial infections now require the last line of antibiotics or are untreatable. The current antibiotic of last resort for carbapenem-resistant Gram-negative bacterial infections is often colistin. Evidence for the shifting pattern of colistin resistance and how the international community should respond are discussed in this review. Methods: The literature on colistin resistance was reviewed. Results: Plasmid-mediated colistin resistance encoded by mcr-1 was first documented in China during the routine surveillance of food animals. This has been followed by similar reports across a wide geographic area, in humans, animals, and the environment. The mcr-1 gene has been reported among human isolates in 29 countries, related to environmental samples in four countries, and in food animals and other animals in 28 countries. More recently, a second gene encoding resistance, mcr-2, has been isolated from porcine and bovine Escherichia coli. Conclusion: The emergence and horizontal transmission of colistin resistance highlights the need for heightened stewardship efforts across the One Health platform for this antibiotic of last resort, and indeed for all antibiotics used in animals and humans. (C) 2016 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
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