期刊
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
卷 54, 期 -, 页码 39-42出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijid.2016.11.010
关键词
Escherichia coli; Sequence type 131; Extended-Spectrum-beta-Lactamase; Community-onset infection
资金
- National Health Insurance Service Ilsan hospital [CR 2016-02]
Background: The recent molecular epidemiology of ESBL-producing Escherichia coli infection in two Korean community hospitals was evaluated in this prospective observational study. Methods: We collected non-duplicated E. coli isolates from consecutive, sequentially encountered patients with community-onset episodes between March and April 2016 in two community hospitals in Gyeonggi-do province, Korea. We studied the prevalence, clinical characteristics and molecular epidemiology of E. coli sequence type 131 (ST131) isolated from the community. Results: From a total of 213 E. coli isolates collected from the community, 94 (44.1%) were communityonset healthcare-associated isolates and 119 (55.9%) were community-associated isolates, of which urinary tract infection was the majority. A total of 55 (25.8%) of the 213 E. coli isolates were confirmed to have ESBL genes, which were mainly CTX-M types such as CTX-M-14 and CTX-M-15. There was no difference in the proportion of globally epidemic ST131 clones or that of O25, O16, H30, or H30Rx subclones between community-associated and community-onset healthcare-associated isolates. Conclusions: In this study, considerable ST131 E. coli isolations in the community were observed and about half of them were related to the history of a visit to the healthcare facilities, indicating the spread of multidrug-resistant E. coli to the community via healthcare facilities. (C) 2016 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
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