期刊
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
卷 56, 期 -, 页码 212-220出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijid.2016.12.024
关键词
tuberculosis; natural product; drug development; clinical trial
资金
- National Health and Medical Research Council (NHMRC) [APP1084266, APP1082533]
- NHMRC Centre of Research Excellence in Tuberculosis Control [APP1043225]
Tuberculosis (TB) continues to be a significant cause of mortality and morbidity worldwide. An estimated 2 billion individuals are infected with Mycobacterium tuberculosis and annually there are approximately 10 million new cases of clinical TB and 1.5 million deaths. Currently available drugs and vaccines have had no significant impact on TB control. In addition, the emergence of drug resistant TB is considered a public health crisis, with some strains now resistant to all available drugs. Unfortunately, the growing burden of antibiotic resistance is coupled with decreased effort in the development of new antibiotics. Natural sources are attractive starting points in the search for anti- tubercular drugs because they are extremely rich in chemical diversity and have privileged antimicrobial activity. This review will discuss recent advances in the development of TB drug leads from natural products, with a particular focus on antimycobacterial compounds in late- stage preclinical and clinical development. (C) 2016 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据