Current advances ofDendrobium officinalepolysaccharides in dermatology: a literature review

Context Dendrobium officinaleKimura et Migo (Orchidaceae) is a naturally occurring precious traditional Chinese medicine (TCM) originally used in treating yin-deficiency diseases. The main active substances ofDendrobium officinaleare polysaccharides (DOP). Recent findings highlighted the potential of DOP as a promising natural material for medical use with a diversity of pharmaceutical effects. Objective In this review, we provide a systematic discussion of the current development and potential pharmacological effects ofDendrobium officinalepolysaccharides in dermatology. Methods English and Chinese literature from 1987 to 2019 indexed in databases including PubMed, PubMed Central, Web of Science, ISI, Scopus and CNKI (Chinese) was used.Dendrobium officinale, Dendrobium officinalepolysaccharides, phytochemistry, chemical constituents, biological activities, and pharmacological activities were used as the key words. Results Dendrobium officinalepolysaccharides have been found to possess hair growth promoting, skin moisturising and antioxidant effects, which are highly valued by doctors and cosmetic engineers. We highlighted advances in moisturising and antioxidant properties fromin vivoandin vitrostudies.Dendrobium officinalepolysaccharides exhibited strong antioxidant effects by decreasing free radicals, enhancing antioxidant system, inhibiting nuclear factor-kappa B and down-regulating inflammatory response. Conclusions Our review is a foundation to inspire further research to facilitate the application ofDendrobium officinalepolysaccharides in dermatology and promote active research of the use of TCM in dermatology.