期刊
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
卷 30, 期 3, 页码 207-214出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0394632017714175
关键词
liver enzymes; oxidative stress; rutin; thioacetamide; toxicity
资金
- Deanship of Scientific Research, King Saud University, Research Group [RG-1438-042]
This study was designed to evaluate the effect of rutin on hepatotoxicity induced by thioacetamide (TAA) in rats. Four groups of male Wistar rats consisting of six rats each were used: Group I: control group; Group II: rats receiving single injection of 300mgkg(-1)body weight of TAA intraperitoneally; Group III: rats administered rutin (10mgkg(-1)body weight) dissolved in saline orally for 2weeks; and Group IV: rats administered rutin (10mgkg(-1)body weight) dissolved in saline orally for 2weeks followed by TAA injection last day of second week. All groups were sacrificed after 24h of treatment and hepatic toxicity was analyzed with respect to liver toxicity markers, liver DNA fragmentation, and histology of liver tissue. Administration of TAA in Wistar rats resulted in significant increase of hepatic markers, DNA fragmentation in the hepatocytes, and changes in histology. Pretreatment of rats with rutin before 2weeks of TAA assault resulted in the complete reversal of TAA-mediated hepatic toxicity (P<0.0001 to P<0.01) with concomitant restoration of DNA fragmentation. This study suggests rutin as a protective agent for restoration of toxicity caused by TAA.
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