期刊
CURRENT OPINION IN IMMUNOLOGY
卷 36, 期 -, 页码 115-126出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2015.08.002
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资金
- children and families of the COPSAC
- Intramural Research Program of the NIH, National Institute of Allergy and Infectious Diseases
- Lundbeck Foundation
- Danish Ministry of Health
- Danish Council for Strategic Research
- Danish Council for Independent Research
- Capital Region Research Foundation
- Lundbeck Foundation [R163-2013-16235] Funding Source: researchfish
Our understanding of the specific genetic lesions in allergy has improved in recent years due to identification of common risk variants from genome-wide association studies (GWAS) and studies of rare, monogenic diseases. Large-scale GWAS have identified novel susceptibility loci and provided information about shared genetics between allergy, related phenotypes and autoimmunity. Studies of monogenic diseases have elucidated critical cellular pathways and protein functions responsible for allergy. These complementary approaches imply genetic mechanisms involved in Th2 immunity, T-cell differentiation, TGF beta signaling, regulatory T-cell function and skin/mucosal function as well as yet unknown mechanisms associated with newly identified genes. Future studies, in combination with data on gene expression and epigenetics, are expected to increase our understanding of the pathogenesis of allergy.
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