期刊
CHEMICAL SCIENCE
卷 11, 期 27, 页码 7023-7030出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0sc02393k
关键词
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资金
- Colloid Science PhD studentship from the School of Chemistry (University of Manchester, UK)
- EPRSC [EP/P027067/1, EP/N009134/1, EP/K039547]
- Erasmus+ Traineeship
- European Union's Horizon 2020 Research and Innovation Programme [720793]
- Leverhulme Trust (Philip Leverhulme Prize)
- European Research Council (ERC) under the European Union's Seventh Framework Programme [336935]
- EPSRC [EP/N009134/1, EP/P027067/1] Funding Source: UKRI
Synthetic ion channels may have applications in treating channelopathies and as new classes of antibiotics, particularly if ion flow through the channels can be controlled. Here we describe triazole-capped octameric alpha-aminoisobutyric acid (Aib) foldamers that switch on ion channel activity in phospholipid bilayers upon copper(ii) chloride addition; activity is switched off upon copper(ii) extraction. X-ray crystallography showed that CuCl(2)complexation gave chloro-bridged foldamer dimers, with hydrogen bonds between dimers producing channels within the crystal structure. These interactions suggest a pathway for foldamer self-assembly into membrane ion channels. The copper(ii)-foldamer complexes showed antibacterial activity againstB. megateriumstrain DSM319 that was similar to the peptaibol antibiotic alamethicin, but with 90% lower hemolytic activity.
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