期刊
JOURNAL OF CANCER
卷 11, 期 17, 页码 5236-5244出版社
IVYSPRING INT PUBL
DOI: 10.7150/jca.46200
关键词
hyperuricemia; cancer risk; metabolic syndrome; liver metastasis; uric acid-lowering agents
类别
资金
- Health and Family Planning Commission of Zhejiang Province [2015RCB026]
In recent years, metabolic syndrome (Mets) has been a hot topic among medical scientists. Mets has an intimate relationship with the incidence and development of various cancers. As a contributory factor of Mets, hyperuricemia actually plays an inseparable role in the formation of various metabolic disorders. Although uric acid is classically considered an antioxidant with beneficial effects, mounting evidence indicates that a high serum uric acid (SUA) level may serve as a pro-oxidant to generate inflammatory reactions and oxidative stress. In this review, we describe the unrecognized role of hyperuricemia in cancer development and summarize major mechanisms linking uric acid to carcinogenesis. Furthermore, we also discuss the potential mechanism of liver metastasis of cancer and list some types of uric acid-lowering agents, which may exert anticancer effects.
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