4.7 Article

LMCT transition-based red-light photochemotherapy using a tumour-selective ferrocenyl iron(iii) coumarin conjugate

期刊

CHEMICAL COMMUNICATIONS
卷 56, 期 57, 页码 7981-7984

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ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc03240a

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资金

  1. Department of Biotechnology (DBT), Government of India [BT/401/NE/U-Excel/2013, BT/PR25668/NER/95/1278/2017]
  2. DBT
  3. Council of Scientific and Industrial Research (CSIR, direct-SRF scheme), New Delhi

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A rationally designed iron(iii) complex (2a) with pendant ferrocene and naturally occurring coumarin (esculetin) shows LMCT transition-based mitochondria-targeted red-light (600-720 nm) induced apoptotic toxicity against cancer cells but remains innocuous in the dark and to normal cells.

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