期刊
CHEMICAL COMMUNICATIONS
卷 56, 期 57, 页码 7949-7952出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc02976a
关键词
-
资金
- European Research Council [742987, 788231-ProgrES-ERC-2017-ADG]
- EU [737395]
- BBSRC [BB/M027791/1, BB/M02903411, BB/M028836/1]
- Industrial Biotechnology Innovation Centre (IBioIC)
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/S010459/1]
- Prozomix Ltd.
- BBSRC [BB/M028836/1, BB/M027791/1, BB/S010459/1] Funding Source: UKRI
- EPSRC [EP/S01778X/1] Funding Source: UKRI
Multi-enzyme cascades utilising variants of galactose oxidase and imine reductase led to the successful conversion ofN-Cbz-protectedl-ornithinol andl-lysinol tol-3-N-Cbz-aminopiperidine andl-3-N-Cbz-aminoazepane respectively, in up to 54% isolated yield. Streamlining the reactions into one-pot prevented potential racemisation of key labile intermediates and led to products with high enantiopurity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据