Synthesis of protected 3-aminopiperidine and 3-aminoazepane derivatives using enzyme cascades

Multi-enzyme cascades utilising variants of galactose oxidase and imine reductase led to the successful conversion ofN-Cbz-protectedl-ornithinol andl-lysinol tol-3-N-Cbz-aminopiperidine andl-3-N-Cbz-aminoazepane respectively, in up to 54% isolated yield. Streamlining the reactions into one-pot prevented potential racemisation of key labile intermediates and led to products with high enantiopurity.