期刊
CURRENT OPINION IN GENETICS & DEVELOPMENT
卷 35, 期 -, 页码 79-85出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2015.10.004
关键词
-
资金
- Finnish Cultural Foundation [151027]
- Academy of Finland [258827, 259505]
- Academy of Finland (AKA) [258827, 259505, 259505, 258827] Funding Source: Academy of Finland (AKA)
Polyketides and nonribosomal peptides are important secondary metabolites that exhibit enormous structural diversity, have many pharmaceutical applications, and include a number of clinically important drugs. These complex metabolites are most commonly synthesized on enzymatic assembly lines of polyketide synthases and nonribosomal peptide synthetases. Genome-mining studies making use of the recent explosion in the number of genome sequences have demonstrated unexpected enzymatic diversity and greatly expanded the known distribution of these enzyme systems across the three domains of life. The wealth of data now available suggests that genome-mining efforts will uncover new natural products, novel biosynthetic mechanisms, and shed light on the origin and evolution of these important enzymes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据