期刊
CURRENT OPINION IN GENETICS & DEVELOPMENT
卷 33, 期 -, 页码 10-16出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2015.06.005
关键词
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资金
- Australian NHMRC [1062227]
- Career Development Fellowship
- NHMRC
- Heart Foundation [1061435]
- NHMRC Peter Doherty Early Career Fellowship [1090462]
- National Health and Medical Research Council of Australia [1090462, 1062227] Funding Source: NHMRC
Recent advances in genome-wide association studies have stimulated interest in the genomic prediction of disease risk, potentially enabling individual-level risk estimates for early intervention and improved diagnostic procedures. Here, we review recent findings and approaches to genomic prediction model construction and performance, then contrast the potential benefits of such models in two complex human diseases, aiding diagnosis in celiac disease and prospective risk prediction for cardiovascular disease. Early indications are that optimal application of genomic risk scores will differ substantially for each disease depending on underlying genetic architecture as well as current clinical and public health practice. As costs decline, genomic profiles become common, and popular understanding of risk and its communication improves, genomic risk will become increasingly useful for the individual and the clinician.
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