期刊
CHEMICAL COMMUNICATIONS
卷 56, 期 58, 页码 8115-8118出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc02522d
关键词
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资金
- National Nature Science Foundation of China [21572027]
- Chongqing Science and Technology Bureau [csts2019jcyj-zdxmX0021]
- Chongqing Postdoctoral Science Special Foundation [XmT2019023]
A rationally designed mannosylated amphiphilic pillar[5]arene (Man@AP5) self-assembles into supramolecular vesicles with encapsulated vancomycin (Man@AP5-Van), which target macrophages, respond to both acid and cathepsin B, and release vancomycin (Van) rapidly inside macrophages. Man@AP5-Van significantly increases the intracellular concentration of Van, enhancing its antibacterial efficacy against intracellular MRSA.
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