期刊
DRUG DISCOVERIES AND THERAPEUTICS
卷 14, 期 3, 页码 143-144出版社
INT RESEARCH & COOPERATION ASSOC BIO & SOCIO-SCIENCES ADVANCEMENT
DOI: 10.5582/ddt.2020.03046
关键词
COVID-19; cytokine storm; lymphocyte; Kv1.3-channels; chloroquine
资金
- MEXT KAKENHI Grant [16K08484]
- Salt Science Research Foundation [2028]
- Tojuro Iijima Foundation for Food Science and Technology [2019-12]
- National Institute for Physiological Sciences [19-305]
- Grants-in-Aid for Scientific Research [16K08484] Funding Source: KAKEN
In the midst of a pandemic, finding effective treatments for coronavirus disease 2019 (COVID-19) is the urgent issue. In chronic inflammatory diseases, the overexpression of delayed rectifier K+-channels (Kv1.3) in leukocytes is responsible for the overactivation of cellular immunity and the subsequent cytokine storm. In our previous basic studies, drugs including chloroquine and azithromycin strongly suppressed the channel activity and pro-inflammatory cytokine production from lymphocytes. These findings suggest a novel pharmacological mechanism by which chloroquine, with or without azidunmycin, is effective for severe cases of COVID-19, in which the overactivation of cellular immunity and the subsequent cytokine storm are responsible for the pathogenesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据