期刊
FOOD & FUNCTION
卷 11, 期 7, 页码 6565-6572出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0fo00161a
关键词
-
资金
- Department of Education of Liaoning Provincial Natural Science Foundation of China [QN2019031]
Fructo-oligosaccharides (FOS), an important prebiotic, have been proved to have a beneficial effect on Alzheimer's disease (AD); however, the specific mechanism remains to be confirmed. Senile plaques are one of the main neuropathological features of AD and the core of senile plaques mainly consists of extracellular beta-amyloid (A beta). Reducing A beta accumulation in the brain is an important therapeutic strategy for AD. Neprilysin (NEP), a major A beta-degrading enzyme, has been found to be decreased in the AD brain. Evidence has shown that the expression of NEP is associated with histone acetylation levels. Histone deacetylases (HDACs) are the key enzymes in the modulation of histone acetylation modification. Importantly, several metabolites of FOS have been demonstrated to be pan-HDAC inhibitors. In this study, we demonstrate that FOS ameliorate cognitive impairment and alleviate A beta accumulation in the brain of AD model mice. The regulation of HDAC2 on NEP plays an important role in the anti-AD effect of FOS.
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