期刊
FOOD & FUNCTION
卷 11, 期 7, 页码 5898-5914出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9fo02761k
关键词
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资金
- National Natural Science Foundation of China [31671839]
- National Natural Science Foundation of China Key Program [31530056]
- Fundamental Research Funds for the Central Universities [JUSRP51501]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- national first-class discipline program of Food Science and Technology [JUFSTR20180102]
- Program of Collaborative Innovation Centre of Food Safety and Quality Control in Jiangsu Province
- Natural Science Foundation of Jiangsu Province [BK20180613]
- China Postdoctoral Science Foundation [2018M642164]
- Postdoctoral Science Foundation of Jiangsu Province [2018K090C]
- Fan Daiming Academician Workstation Fund of Wuxi Second People's Hospital [CYR1705]
- Key Discipline Construction Project for Gastroenterology [ZDXK002]
The prevalence of diabetes mellitus is increasing worldwide. Lactic acid bacteria have shown efficacy in alleviating diabetes. We studied the remission effect of nine strains of lactic acid bacteria on the symptoms of high-fat diet- and streptozotocin-induced type 2 diabetes and its mechanism in mice. The oral administration ofBifidobacterium adolescentis,B. bifidumorLactobacillus rhamnosusto mice every day for more than 12 weeks showed that the individual strains could reduce the fasting and postprandial blood sugar levels, improve glucose tolerance and prevent pancreatic damage. However,L. rhamnosusstrains showed greater efficacy thanBifidobacteriumstrains in the regulation of blood lipid levels. The effects of lactic acid bacteria on the recovery of glycolipid metabolism disorder and gut microbiota dysbiosis showed inter- and intraspecific differences. In addition, the strains that exhibited hypoglycaemic effects played a beneficial role in reducing insulin resistance by contributing to the production of short-chain fatty acids and alleviation of inflammation. The ability of lactic acid bacteria to reduce inflammation was found to be closely related to their ability to alleviate diabetes mellitus.
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