期刊
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
卷 137, 期 3, 页码 290-294出版社
WILEY
DOI: 10.1002/ijgo.12141
关键词
Asthma; Childhood; Maternal factors; Neonate; Perinatal factors; Pregnancy; Prematurity; Prenatal factors
Objective: To identify prenatal and perinatal risk factors for childhood asthma. Methods: A retrospective case-control study was undertaken among children aged 7-14years in Tehran, Iran, between March 2009 and November 2014. Data for children with asthma (Iranian nationality, non-smoking parents, and middle-class socioeconomic status) were compared with those for an equal number of age- and sex-matched non-asthmatic children. Prenatal and perinatal risk factors were evaluated via complete data sheets of maternal pregnancy and delivery. Forward logistic regression analysis was performed. Results: Both groups contained 134 children. Risk of asthma was shown to be associated with maternal history of asthma (adjusted odds ratio [aOR] 11.62, 95% confidence interval 1.38-96.93; P=0.024), vaginal bleeding during pregnancy (aOR 3.76, 95% CI 1.86-7.57; P<0.001), antibiotics during pregnancy (aOR 3.19, 95% CI 1.52-6.67; P=0.002), and maternal age 30years or older (aOR 2.54, 95% CI 1.30-4.95; P=0.006). Breastfeeding was protective against childhood asthma (aOR 0.29, 95% CI 0.151-0.575; P<0.001). Conclusion: History of maternal asthma was the most influential factor on development of childhood asthma, followed by vaginal bleeding during pregnancy, antibiotic exposure in utero, and older maternal age.
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