期刊
MOLBANK
卷 2020, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/M1122
关键词
muraymycins; caprazamycins; nucleosides; uridine; cyclization; seven-membered rings
资金
- Deutsche Forschungsgemeinschaft (DFG) [DU 1095/5-1]
- Saarland University
Naturally occurring nucleoside-peptide antibiotics such as muraymycins or caprazamycins are of major interest for the development of novel antibacterial agents. However, the synthesis of new analogues of these natural products for structure-activity relationship (SAR) studies is challenging. In our synthetic efforts towards a muraymycin-derived nucleoside building block suitable for attachment to a solid support, we came across an interesting side product. This compound resulted from an undesired Fmoc deprotection with subsequent cyclization, thus furnishing a remarkable caprazamycin-like seven-membered diazepanone ring.
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