期刊
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
卷 18, 期 6, 页码 552-558出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MCO.0000000000000221
关键词
autism; gut microbiota; major depression; Parkinson's disease; psychobiotics
资金
- Science Foundation Ireland (Alimentary Pharmabiotic Centre) [SFI/12/RC/2273]
- Health Research Board of Ireland [HRA_POR/2011/23, HRA_POR/2012/32]
- European Community [FP7/2007-2013]
Purpose of review The gut microbiota has become a focus of research for those interested in the brain and behaviour. Here, we profile the gut microbiota in a variety of neuropsychiatric syndromes. Recent findings Multiple routes of communication between the gut and brain have been established and these include the vagus nerve, immune system, short chain fatty acids and tryptophan. Developmentally, those born by caesarean section have a distinctly different microbiota in early life to those born per vaginum. At the other extreme, individuals who age with considerable ill-heath tend to show narrowing in microbial diversity. Recently, the gut microbiota has been profiled in a variety of conditions including autism, major depression and Parkinson's disease. There is still debate as to whether or not these changes are core to the pathophysiology or merely epiphenomenal. Summary The current narrative suggests that certain neuropsychiatric disorders might be treated by targeting the microbiota either by microbiota transplantation, antibiotics or psychobiotics.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据