Remote azidation of C(sp3)-H bonds to synthesize δ-azido sulfonamides via iron-catalyzed radical relay

With an iron catalyst playing dual roles as a radical initiator and terminator, we report a selective remote C-H functionalization to access delta-azido sulfonamides through a radical relay process. The reaction ofN-fluorosulfonamide furnishes the corresponding products in excellent yields with high regioselective control. The key to success is the highly efficient iron-mediated redox azido transfer to thein situgenerated carbon radical. The products provide incentives for drug discovery and ligand designs.