期刊
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
卷 33, 期 2, 页码 325-331出版社
WILEY
DOI: 10.1002/gps.4747
关键词
small vessel disease score; white matter hyperintensities; cerebral microbleeds; lacunar infarctions; enlarged perivascular spaces; population-based study
资金
- Universidad Espiritu Santo-Ecuador, Guayaquil-Ecuador
ObjectiveCerebral small vessel disease (SVD) is inversely associated with cognitive performance. However, whether the total SVD score is a better predictor of poor cognitive performance than individual signatures of SVD is inconclusive. We aimed to estimate the combined and independent predictive power of these MRI findings. MethodsAtahualpa residents aged 60years underwent brain MRI. Cognitive performance was measured by the Montreal Cognitive Assessment (MoCA). The presence of moderate-to-severe white matter hyperintensities, deep cerebral microbleeds, lacunar infarcts, and >10 enlarged perivascular spaces was added for estimating the total SVD score ranging from 0 to 4 points. Montreal Cognitive Assessment predictive models were fitted to assess how well the total SVD score or each of its components predicts cognitive performance. ResultsOf 351 eligible candidates, 331 (94%) were included. The total SVD score was 0 points in 202 individuals (61%), 1 point in 67 (20%), 2 points in 40 (12%), 3 points in 15 (5%), and 4 points in seven (2%). A generalized lineal model showed an inverse relationship between the total SVD score and the MoCA (p=0.015). The proportion of variance in the MoCA score explained by the SVD score was 32.8% (R-2=0.328). This predictive power was similar for white matter hyperintensities (R-2=0.306), microbleeds (R-2=0.313), lacunar infarcts (R-2=0.323), and perivascular spaces (R-2=0.313). ConclusionsThis study shows a significant association between the SVD score and worse cognitive performance. The SVD score is a predictor of poor cognitive performance. This predictive power is not better than that of isolated neuroimaging signatures of SVD. Copyright (c) 2017 John Wiley & Sons, Ltd.
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