期刊
NANOSCALE
卷 12, 期 28, 页码 15275-15282出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0nr00143k
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资金
- National Science Fund for Distinguished Young Scholars [31825012]
- National Key Research and Development Program of China [2017YFC1103502]
- Fundamental Research Funds for the Central Universities [ZB19100123]
- NSFC [31670973, 31870949, 21875116]
- Tianjin Science Fund for Distinguished Young Scholars [17JCJQJC44900]
Nuclear delivery of anticancer drugs, particularly dual complementary anticancer drugs, can significantly improve chemotherapy efficacy. However, successful examples are rare. We reported a novel dual anticancer drug-based nanomedicine with nuclear accumulation properties. The nanomedicine was formed by chelation between a drug peptide amphiphile Rh-GFFYERGD (Rh represents Rhein, 1,8-dihydroxy-3-carboxy anthraquinonea) and cisplatinum (Pt). A single molecule of the drug peptide amphiphile could chelate up to 8 equiv. of cisplatinum in the resulting nanofibers. The nanofibers with a 1 : 4 ratio of Rh-GFFYERGD to cisplatinum demonstrated remarkable cellular uptake, and more significantly, superior nuclear accumulation properties. Additionally, the nanofibers could also bind to the DNA molecule more efficiently than those formed by the drug peptide amphiphile. Thus the nanofibers exhibited excellent anticancer properties bothin vitroandin vivo. We envision a significant therapeutic potential of the dual anticancer drug-based nanomedicine with cisplatinum in cancer.
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