期刊
NATURAL PRODUCT REPORTS
卷 37, 期 7, 页码 868-878出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9np00045c
关键词
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资金
- Vanderbilt University Discovery Grant
- Howard Hughes Medical Institute through the James H. Gilliam Fellowships for Advanced Study program
- National Science Foundation [DEB1442113]
- Guggenheim Foundation
- Burroughs Wellcome Fund
- National Cancer Institute [P01 CA125066]
- Regular Faculty Grant (from the University of North Carolina at Greensboro)
Covering: up to 2019 Fungi produce a remarkable diversity of secondary metabolites: small, bioactive molecules not required for growth but which are essential to their ecological interactions with other organisms. Genes that participate in the same secondary metabolic pathway typically reside next to each other in fungal genomes and form biosynthetic gene clusters (BGCs). By synthesizing state-of-the-art knowledge on the evolution of BGCs in fungi, we propose that fungal chemodiversity stems from three molecular evolutionary processes involving BGCs: functional divergence, horizontal transfer, andde novoassembly. We provide examples of how these processes have contributed to the generation of fungal chemodiversity, discuss their relative importance, and outline major, outstanding questions in the field.
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