期刊
CURRENT OPINION IN CELL BIOLOGY
卷 35, 期 -, 页码 106-116出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2015.04.016
关键词
-
类别
资金
- National Science and Technology Development Agency
- Development and Promotion of Science and Technology Talents Project [023/2557]
- Thailand Research Fund
- Office of the Higher Education Commission
- Mahidol University
- NIH [GM085273, AI042999, AI111935]
- ACS [126768-IRG-14-187-19]
- Manpei Suzuki Diabetes Foundation
- Uehara Memorial Foundation
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI111935, R01AI042999] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P50GM085273] Funding Source: NIH RePORTER
Autophagy, once viewed exclusively as a cytoplasmic auto-digestive process, has its less intuitive but biologically distinct non-degradative roles. One manifestation of these functions of the autophagic machinery is the process termed secretory autophagy. Secretory autophagy facilitates unconventional secretion of the cytosolic cargo such as leaderless cytosolic proteins, which unlike proteins endowed with the leader (N-terminal signal) peptides cannot enter the conventional secretory pathway normally operating via the endoplasmic reticulum and the Golgi apparatus. Secretory autophagy may also export more complex cytoplasmic cargo and help excrete particulate substrates. Autophagic machinery and autophagy as a process also affect conventional secretory pathways, including the constitutive and regulated secretion, as well as promote alternative routes for trafficking of integral membrane proteins to the plasma membrane. Thus, autophagy and autophagic factors are intimately intertwined at many levels with secretion and polarized sorting in eukaryotic cells.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据