期刊
CURRENT OPINION IN CELL BIOLOGY
卷 35, 期 -, 页码 98-105出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2015.04.015
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资金
- National Institutes of Health [1R01DK090038, 1R01DK099160-01A1]
- P30 center grant [P30DK90728]
- National Cancer Institute (NCI) [1R01CA149039-01A1]
- Susan G. Komen for the Cure [KG100902]
- NATIONAL CANCER INSTITUTE [R01CA149039] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK099160, P30DK090728, R01DK090038] Funding Source: NIH RePORTER
Once thought of as a vestigial organelle, the primary cilium is now recognized as a signaling hub for key cellular pathways in vertebrate development. The recent renaissance in cilia studies significantly improved our understanding of how cilia form and function, but little is known about how ciliogenesis is initiated and how ciliary proteins enter cilia. These important ciliary events require transition fibers (TFs) that are positioned at the ciliary base as symmetric nine-bladed propeller fibrous structures. Up until recently, TFs have been the most underappreciated ciliary structures due to limited knowledge about their molecular composition and function. Here, we highlight recent advances in our understanding of TF composition and the indispensable roles of TFs in regulating the initiation of ciliogenesis and the selective import of ciliary proteins.
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