4.5 Article

Metabolic control via the mitochondrial protein import machinery

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CURRENT OPINION IN CELL BIOLOGY
卷 33, 期 -, 页码 42-48

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CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2014.11.001

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  1. Deutsche Forschungsgemeinschaft
  2. Excellence Initiative of the German Federal Government [EXC 294 BIOSS]
  3. Excellence Initiative of the German State Government [EXC 294 BIOSS]

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Mitochondria have to import most of their proteins in order to fulfill a multitude of metabolic functions. Sophisticated import machineries mediate targeting and translocation of preproteins from the cytosol and subsequent sorting into their suborganellar destination. The mode of action of these machineries has been considered for long time as a static and constitutively active process. However, recent studies revealed that the mitochondrial protein import machinery is subject to intense regulatory mechanisms that include direct control of protein flux by metabolites and metabolic signalling cascades.

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