期刊
CHEMICAL SOCIETY REVIEWS
卷 49, 期 15, 页码 5473-5509出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cs00199a
关键词
-
资金
- HHMI
- NIH
- NSF
- BBSRC
- MRC
- Alzheimer's Society
- Alzheimer's Research UK
- ARC
- AFTAM Research Collaboration Award
- EPSRC [EP/L020599/1]
- Independent Research Council Denmark-Natural Sciences grant [8021-00208B]
- Independent Research Council Denmark-Technical Sciences grant [6111-00241]
- NIH [R01GM118651]
- DFG [FA 456/27]
- EPSRC [EP/L020599/1] Funding Source: UKRI
Amyloid diseases are global epidemics with profound health, social and economic implications and yet remain without a cure. This dire situation calls for research into the origin and pathological manifestations of amyloidosis to stimulate continued development of new therapeutics. In basic science and engineering, the cross-beta architecture has been a constant thread underlying the structural characteristics of pathological and functional amyloids, and realizing that amyloid structures can be both pathological and functional in nature has fuelled innovations in artificial amyloids, whose use today ranges from water purification to 3D printing. At the conclusion of a half century since Eanes and Glenner's seminal study of amyloids in humans, this review commemorates the occasion by documenting the major milestones in amyloid research to date, from the perspectives of structural biology, biophysics, medicine, microbiology, engineering and nanotechnology. We also discuss new challenges and opportunities to drive this interdisciplinary field moving forward.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据