期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 34, 期 -, 页码 153-161出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.copbio.2014.12.020
关键词
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资金
- Wellcome Trust [RG 093735/Z/10/Z]
- ERC [260809]
- Austrian Science Funds by an Erwin Schroeder postdoctoral fellowship (FWF) [J 3341]
- Austrian Science Fund (FWF) [J 3341] Funding Source: researchfish
- The Francis Crick Institute [10134] Funding Source: researchfish
Enzymes shape cellular metabolism, are regulated, fast, and for most cases specific. Enzymes do not however prevent the parallel occurrence of non-enzymatic reactions. Nonenzymatic reactions were important for the evolution of metabolic pathways, but are retained as part of the modern metabolic network. They divide into unspecific chemical reactivity and specific reactions that occur either exclusively non-enzymatically as part of the metabolic network, or in parallel to existing enzyme functions. Non-enzymatic reactions resemble catalytic mechanisms as found in all major enzyme classes and occur spontaneously, small molecule (e.g. metal-) catalyzed or light-induced. The frequent occurrence of non-enzymatic reactions impacts on stability and metabolic network structure, and has thus to be considered in the context of metabolic disease, network modeling, biotechnology and drug design.
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