期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 36, 期 -, 页码 176-182出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2015.08.021
关键词
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资金
- Ecole Polytechnique Federale de Lausanne (EPFL)
- Swiss National Science Foundation
- RTD grant MetaNetX within SystemsX.ch
- RTD grant MicroscapesX within SystemsX.ch
- Swiss Initiative for Systems Biology
Thermodynamics-based network analysis through the introduction of thermodynamic constraints in metabolic models allows a deeper analysis of metabolism and guides pathway engineering. The number and the areas of applications of thermodynamics-based network analysis methods have been increasing in the last ten years. We review recent applications of these methods and we identify the areas that such analysis can contribute significantly, and the needs for future developments. We find that organisms with multiple compartments and extremophiles present challenges for modeling and thermodynamics-based flux analysis. The evolution of current and new methods must also address the issues of the multiple alternatives in flux directionalities and the uncertainties and partial information from analytical methods.
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