期刊
CURRENT OPINION IN BIOTECHNOLOGY
卷 31, 期 -, 页码 86-92出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.copbio.2014.08.007
关键词
-
资金
- 973 Program [2013CB531200]
- NSFC [31225008, 91313301, 31071260, 31170815]
- Specialized Research Fund for the Doctoral Program of Higher Education [20100074110010]
- Shanghai Science and Technology Commission [12JC1402900, 14XD1401400, 11DZ2260600]
- Dawn Program of Shanghai Education Commission [11SG31]
- 111 Project [B07023]
- Fundamental Research Funds for the Central Universities
NADH and its oxidized form, NAD(+), play central roles in energy metabolism and are ideal indicators of cellular metabolic states. In this review, we will introduce recent progress made in the developing of a series of genetically encoded NADH sensors, which offer the potential to fill the gap in currently used techniques of endogenous NAD(P)H fluorescence imaging. These sensors are bright, specific and organelles targetable, allowing real-time tracking and quantification of intracellular NADH levels in different subcellular compartments. The individual strengths and weaknesses of these sensors when applied to the study of metabolic states profiling will be also discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据