期刊
RESPIROLOGY CASE REPORTS
卷 8, 期 6, 页码 -出版社
WILEY
DOI: 10.1002/rcr2.607
关键词
Danazol; interstitial lung disease; non-specific interstitial pneumonia; telomere
We report the case of a 42-year-old female with a history of finger clubbing which improved during pregnancy, a history of unexplained hepatosplenomegaly, and subsequent non-specific interstitial pneumonia with respiratory failure. Given a personal and family history of early greying of the hair, the peripheral blood monocyte telomere length was measured and was confirmed to be <1st centile, explaining the multiorgan presentation. She was treated with prednisolone, mycophenolate mofetil, and the synthetic androgen danazol with a dramatic improvement in respiratory failure and lung function. After 18 months of danazol treatment, the peripheral blood monocyte telomere length had returned to the normal range.
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