期刊
CHEMICAL COMMUNICATIONS
卷 56, 期 59, 页码 8210-8213出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc02734k
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Formation of all-carbon-substituted quaternary carbons is a key challenge in organic and medicinal chemistry. We report a cobalt-catalyzed C(sp(3))-C(sp(3)) cross-coupling that allows for the introduction of benzyl, heteroarylmethylzinc and allyl groups to halo-carbonyl substrates. The cross-coupling reaction is selective for C(sp(3))-over C(sp(2))-halides, in contrast to most used catalytic metals, and allows access to novel scaffolds of pharmaceutical interest. NMR mechanistic studies suggest the presence of Co(0) complexes as catalytic species.
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