期刊
JOURNAL OF THE ENDOCRINE SOCIETY
卷 4, 期 8, 页码 -出版社
ENDOCRINE SOC
DOI: 10.1210/jendso/bvaa087
关键词
glucocorticoid; estrogen; androgen; progestogen; crosstalk; sex-specific; metabolism; diabetes; developmental programming; endocrine-disrupting chemicals
资金
- National Institutes of Health [R21 ES021354, R01 ES028879, T32 HD007009, P30 ES027792]
Early-life exposures to environmental insults can misprogram development and increase metabolic disease risk in a sex-dependent manner by mechanisms that remain poorly characterized. Modifiable factors of increasing public health relevance, such as diet, psychological stress, and endocrine-disrupting chemicals, can affect glucocorticoid receptor signaling during gestation and lead to sex-specific postnatal metabolic derangements. Evidence from humans and animal studies indicate that glucocorticoids crosstalk with sex steroids by several mechanisms in multiple tissues and can affect sex-steroid-dependent developmental processes. Nonetheless, glucocorticoid sex-steroid crosstalk has not been considered in the glucocorticoid-induced misprogramming of metabolism. Herein we review what is known about the mechanisms by which glucocorticoids crosstalk with estrogen, androgen, and progestogen action. We propose that glucocorticoid sex-steroid crosstalk is an understudied mechanism of action that requires consideration when examining the developmental misprogramming of metabolism, especially when assessing sex-specific outcomes. (C) Endocrine Society 2020.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据