期刊
JOURNAL OF THE ENDOCRINE SOCIETY
卷 4, 期 7, 页码 -出版社
ENDOCRINE SOC
DOI: 10.1210/jendso/bvaa062
关键词
carbohydrate; obesity; insulin; beta-hydroxybutyrate; glucose; fatty acids
资金
- Nutrition Science Initiative
- New Balance Foundation
- Many Voices Foundation
- Blue Cross Blue Shield
- Pediatric Endocrine Society fellowship
- National Institute of Diabetes and Digestive and Kidney Diseases [K24DK082730]
Context: According to the carbohydrate-insulin model of obesity, an elevated insulin-to-glucagon ratio in response to a high-carbohydrate diet directs metabolic fuels toward storage, resulting in lower circulating energy. Objective: To determine differences in total circulating energy post-meal related to dietary carbohydrate. Design: Ancillary study within the Framingham State Food Study. Setting: University community. Participants: 29 adults (aged 20 to 65 years) with overweight or obesity (body mass index >= 25 kg/m(2)) Intervention: After achieving 10% to 14% weight loss on a run-in diet, participants were randomized cs) to weight-loss-maintenance test diets varying in carbohydrate content (high-carbohydrate, 60% of total energy, n = 11; moderate-carbohydrate, 40%, n = 8; low-carbohydrate, 20%, n = 10) and controlled for protein (20%). During 24-hour metabolic ward admissions between 10 and 15 weeks on the test diets, metabolic fuels and hormones were measured. Main Outcome Measure: Energy availability (EA) based on energy content of blood glucose, beta-hydroxybutyrate, and free fatty acids, in the late postprandial period (180 to 300 minutes). insulin at N minutes into the test meal (Meal Insulin-30) was measured as an effect modifier. Results: Insulin-to-glucagon ratio was 7-fold higher in participants on the high- vs low-carbohydrate diet (2.5 and 0.36, respectively). Late postprandial EA was 0.58 kcal/L lower on the high- vs low-carbohydrate diet (P < 0.0001), primarily related to suppression of free fatty acids. Early postprandial EA (30 to 180 minutes) declined fastest in the high-carbohydrate group, and Meal Insulin-30 modified this diet effect. Conclusions: During weight-loss maintenance on a high-carbohydrate diet, late postprandial EA is reduced, consistent with the carbohydrate-insulin model. (C) Endocrine Society 2020.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据