The effects of Finasteride on the expression of DazI, Tsga10, Sycp3, Prm2 genes during spermatogenesis in testes of NMRI mice

OBJECTIVE: In this study, the impact of Finasteride was assessed on the expression of four biomarkers of the spermatogenesis process, namely Dazl, Tsga10, Sycp3, and Prm2 using the Real -Time PCR technique. MATERIALS AND METHODS: The experimental protocol was carried out on male NMRI mice for 35 days in which three animal groups received three different doses of Finasteride (1, 5, and 20 mg/body weight). RESULTS: The results showed that the expression levels of both Dazi and Prm2 genes were significantly decreased only at a dose of 20 mg/body weight, but at doses of 5 and 20 mg/body weight, the expression levels of Sycp3 and Tsga10 genes were significantly reduced. CONCLUSIONS: It seems that Finasteride, at a dose of 5 mg/body weight or higher, may have adverse effects on male spermatogenesis and fertility.