期刊
NATURE REVIEWS IMMUNOLOGY
卷 20, 期 12, 页码 720-726出版社
NATURE PORTFOLIO
DOI: 10.1038/s41577-020-0397-z
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资金
- National Institutes of Health (NIH) [AI095542, DE025884, AI134236, AI134035, T32 GM007200]
- Pfizer
- Crohn's & Colitis Foundation
In this Progress article, Wang and Colonna highlight a flurry of recent reports that have shaped our understanding of how environmental cues and clock genes regulate group 3 innate lymphoid cells. They consider the implications of these findings for intestinal immunity. Each day, the gastrointestinal tract encounters an influx of microbial and nutrient-derived signals and its physiological activities often adhere to a circadian rhythm. As such, group 3 innate lymphoid cells (ILC3s) that reside in the intestinal mucosa must function within a highly dynamic environment. In this Progress article, we highlight a series of recent reports that have characterized the circadian clock in ILC3s. We discuss how these studies have illustrated the roles of environmental cues and clock genes in regulating ILC3 biology and consider the implications for intestinal immunity.
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